Screens | Daikon

Screens

Screens refer to the experimental process of identifying compounds of interest through assays against a biological target or system. DAIKON stores target-based and phenotypic screening information in the Screen component. Both approaches aim to uncover starting points for drug discovery efforts, with target-based screens offering mechanistic precision and phenotypic screens capturing complex, system-level effects.

📄️ Screen Module Structure

The screening module in DAIKON is organized into three main tabs :

📄️ Add a Screen

Create a new target-based or phenotypic screen:

📄️ Add screening efforts to an existing screen

Maintaining updated screening data is critical to ensure oversight of ongoing effort across multiple organization to identify synergies and avoid duplication. This ensures forward progress in the pre-portfolio. Screens should be reviewed on a quarterly basis to ensure that data is up to date. It is recognized that additional libraries may be added to an ongoing screening effort. Within DAIKON you have the flexibility to update screens at any time and in several ways.

📄️ Add Active Hits

Confirmed active hits from screens should be captured in DAIKON. A voting mechanism allows chemists to rate these compounds and prioritize the high-quality hits to proceed to the next phase of Hit Assessment.