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Add Active Hits

Confirmed active hits from screens should be captured in DAIKON. A voting mechanism allows chemists to rate these compounds and prioritize the high-quality hits to proceed to the next phase of Hit Assessment.

To begin adding hits to a screen:

  1. Navigate to the Hits tab within the selected screen, and click on + Add Hit Collection or + Create a Hit Collection.

A Hit Collection is a group of compounds that have shown potential in preliminary screens. A single screen can have multiple hit collections, which can be organized based on any specific criteria. Once the collection is created, you can start adding individual compounds to it



  1. Add information for the following fields, then click ‘Add to Database’:
  • Hit Collection Type: Required dropdown field with options such as Confirmed Active, Disclosed Hits, Others, etc. This helps categorize the collection based on the nature of the hits.
  • Name: Required field to provide a unique and descriptive name for the hit collection.
  • Notes: Optional text field to capture any additional context or relevant details about the collection.

This creates the hit collection, which is now ready for you to import hits.

  1. Hits Menu Bar Overview: Once a hit collection is created, the menu bar in the Hits section appears. It is organized into grouped dropdowns for efficient navigation and access to key features. The top-level headings include:
  • File: This menu provides options for managing hit data files.
    • New Hit: Start entering a new hit manually into the current hit collection.
    • Import Excel: Upload hit data in bulk by importing an Excel file.
      • Click 'Import Excel', a window will appear prompting you to either browse or select an Excel file from your system.
    • Export to Excel: Download the current hit data in Excel format for offline analysis or sharing.
    • Template: Download a standardized Excel template to ensure correct formatting during import.


  • Edit: This menu allows you to modify existing hit entries.
    • Edit Selected Hit: To edit a hit record, use the Edit Pencil in line with the hit.

  • Votes: This menu allows you to manage and view voting activity on hits.
    • Votes Visible: Enables visibility control of vote counts from chemists.
    • One-Click Voting Disabled: Control for quick vote functionality to ensure deliberate, form-based voting in a single click.
    • Filter Not Voted: Displays only those hits that have not yet received votes



  • Tools: Provides more features for organizing hits
    • Cluster: Groups similar hits together based on structural similarity.
      • Set Threshold: Adjust the sensitivity of clustering. A lower threshold shows tighter similarity; higher allows broader grouping.


  • Customize: Allows users to tailor their hit table view to suit individual or team needs.
    • Select Columns: Choose which data columns to display in the hit table (e.g., ID, structure, score, etc.).
      • View Options :
        • Set for Everyone: Applies your current view setup as the default for all users.
        • Personal View: Saves your view settings only for your user profile.